Kwiminyaka ye-1990, iingcali zonyango zaseSwitzerland zifumene ukuba iiplatelet ziyakwazi ukuvelisa inani elikhulu lezinto zokukhula kwiindawo eziphezulu, ezinokukhawuleza kwaye zilungise ngokufanelekileyo izilonda zezicubu.Emva koko, i-PRP isetyenziswe kwiintlobo ezahlukeneyo zotyando lwangaphakathi nangaphandle, utyando lweplastiki, ukutshintshwa kwesikhumba, njl.
Ngaphambili sazisa ukusetyenziswa kwe-PRP (iPlatelets Rich Plasma) ekutshintsheni iinwele ukunceda ukubuyiswa kwesilonda kunye nokukhula kweenwele;Ewe kunjalo, uvavanyo olulandelayo lokuzama kukwandisa ukugqunywa kweenwele eziphambili ngokutofa i-PRP.Makhe sibone ukuba zeziphi iziphumo eziya kuphunyezwa ngokutofa iplasma ephuculweyo ye-autologous kunye nezinto ezahlukeneyo zokukhula kwizigulana ezingamadoda ezine-alopecia, ekwalunyango esinokulindela ukulusebenzisa ukulwa nokulahleka kweenwele.
Ngaphambi nangexesha lenkqubo yonke yokutshintshwa kweenwele, izigulane ziphathwa nge-PRP kunye nezo zingajojowe nge-PRP zingenza iinwele zikhule ngokukhawuleza.Kwangelo xesha, umbhali ukwacebise uphononongo lokuqinisekisa ukuba iplasma etyebileyo yeplatelet inefuthe elifanayo ekuphuculeni iinwele ezintle.Loluphi uhlobo lwesilonda ekufuneka lusetyenziswe kwaye ingakanani into yokukhula ekufuneka itofwe ngokuthe ngqo ukuze isebenze?Ngaba i-PRP ingakwazi ukubuyisela ukuncipha ngokuthe ngcembe kweenwele kwi-alopecia ye-androgenic, okanye ngaba inokukhuthaza ngokufanelekileyo ukukhula kweenwele ukuphucula i-alopecia ye-androgenic okanye ezinye izifo zokulahleka kweenwele?
Kulo vavanyo oluncinci lweenyanga ezisibhozo, i-PRP yafakwa kwi-scalp ye-androgenic alopecia kunye nezifundo ze-alopecia.Xa kuthelekiswa neqela lolawulo, liyakwazi ukubuyisela umva ukuncipha kancinci kweenwele;Ukongezelela, xa ijojowe kwizigulane ezinempandla ejikelezayo, ukukhula kweenwele ezintsha kunokubonwa emva kwenyanga enye, kwaye umphumo unokuhlala ngaphezu kweenyanga ezisibhozo.
Intshayelelo
Kwi-2004, xa omnye wabaphandi ephatha isilonda sehashe nge-PRP, isilonda siphiliswa kwinyanga enye kwaye iinwele zakhula, kwaye ke i-PRP isetyenziselwa utyando lokutshintshwa kweenwele;Abaphandi baphinde bazama ukufaka i-PRP kwi-scalp yezinye izigulane ngaphambi kokutshintshwa kweenwele, kwaye bafumanisa ukuba iinwele zezigulane zibonakala ziba nzima (1).Abaphandi bakholelwa ukuba i-revascularization kunye nesiphumo somxholo ophezulu wokukhula kunokukhuthaza ukukhula kweeseli zeenwele kwi-scalp yendawo engasebenziyo.Igazi licutshungulwa ngokukodwa.Iiplatelets zohlulwe kwezinye iiproteni zeplasma kwaye ziqulathe ukuxinana okuphezulu kweeplatelet.Ukufikelela kumgangatho wesiphumo sonyango, ukusuka kwi-1 microliter (0.000001 ilitha) equkethe i-150000-450000 platelets kwi-1 microliter (0.000001 ilitha) equkethe i-1000000 platelets (2).
I-Platelet α ineentlobo ezisixhenxe zezinto zokukhula kwi-granules, kubandakanywa ukukhula kwe-epithelial factor, i-fibroblast factor factor, i-thrombogen factor factor and transforming factor factor β, ukuguqula ukukhula kwe-α, i-Interleukin-1, kunye ne-vascular endothelial growth factor (VEGF).Ukongezelela, i-peptides ye-antimicrobial, i-catecholamines, i-serotonin, i-Osteonectin, i-von Willebrand factor, i-proaccelenn kunye nezinye izinto zongezwa.Amasuntswana angqindilili aneentlobo ezingaphezu kwe-100 zezinto zokukhula, ezinokusebenza kumanxeba.Ukongeza kwizinto ezikhulayo, i-platelet sparse plasma (PPP) eyodwa iqulethe i-adhesion molecules ezintathu (CAM), i-Fibrin, i-fibronectin, kunye ne-vitronectin, iprotheni esebenzayo eyenza isakhiwo esiphambili kunye namasebe okulawula ukukhula kweeseli, ukunamathela, ukwanda, ukwahlula kunye nokuvuselelwa.
Takakura, et al.ibango lokuba i-PDCF (i-platelet derived growth factor) isignali inxulumene nokusebenzisana kwe-epidermal hair follicles kunye neeseli ze-dermal stromal, kwaye iyimfuneko ekwenzeni imibhobho yeenwele (3).Ngo-2001, uYano et al.yabonisa ukuba i-VFLGF ilawula ubukhulu becala umjikelezo wokukhula kweenwele, inika ubungqina obuthe ngqo bokuthi ukwandisa i-hair follicle vascular reconstruction inokukhuthaza ukukhula kweenwele kunye nokwandisa i-follicle yeenwele kunye nobukhulu beenwele (4).
PS: I-Platelet derived factor growth, PDCF.Into yokuqala yokukhula evunyiweyo yi-US FDA ukunyanga ukulimala okungapheliyo kwesikhumba yinto yokuqala yokukhula ekhutshwe ngokuvuselela emva kokulimala kwesikhumba.
PS: Ukukhula kweVascular endothelial factor, VEGF.Ngenye yezona zinto zibalulekileyo ezilawulayo ezilawula ukwanda kweeseli ze-endothelial, i-angiogenesis, i-vasculogenesis kunye ne-vascular permeability.
Ukuba sikholelwa ukuba xa inwele ziye zacutheka kangangokuba singakwazi ukubona ukukhula kweenwele ngeliso lenyama, kusekho ithuba lokuba inwele zikhule iinwele (5).Ukongeza, ukuba iifolthi zeenwele zeenwele ezicolekileyo ziyafana nezo zeenwele ezirhabaxa, kukho ii-stem cells ezaneleyo kwi-epidermis kunye ne-bulge (6), kuyenzeka ukuba iinwele zibe zincinci kwaye zibe ngqindilili kwinkqayi yamadoda.
(Qaphela: Eli nqaku liprintwe kwakhona. Injongo yenqaku kukudlulisa ulwazi olufanelekileyo ngolwazi ngokubanzi. Inkampani ayithathi xanduva lokuchaneka, ukunyaniseka, ukuba semthethweni komxholo wayo, kwaye enkosi ukuqonda.)
Ixesha lokuposa: Mar-15-2023